High NaCl–induced activation of CDK5 increases phosphorylation of the osmoprotective transcription factor TonEBP/OREBP at threonine 135, which contributes to its rapid nuclear localization

When activated by high NaCl, tonicity-responsive enhancer–binding protein/osmotic response element–binding protein (TonEBP/OREBP) increases transcription of osmoprotective genes. High NaCl activates TonEBP/OREBP by increasing its phosphorylation, nuclear localization, and transactivating activity. I...

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Main Authors: Gallazzini, Morgan, Heussler, Gary E., Kunin, Margarita, Izumi, Yuichiro, Burg, Maurice B., Ferraris, Joan D.
Formato: Artigo
Idioma:Inglês
Publicado em: The American Society for Cell Biology 2011
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Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3046065/
https://ncbi.nlm.nih.gov/pubmed/21209322
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1091/mbc.E10-08-0681
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