Role of hypoxia and glycolysis in the development of multi-drug resistance in human tumor cells and the establishment of an orthotopic multi-drug resistant tumor model in nude mice using hypoxic pre-conditioning

BACKGROUND: The development of multi-drug resistant (MDR) cancer is a significant challenge in the clinical treatment of recurrent disease. Hypoxia is an environmental selection pressure that contributes to the development of MDR. Many cancer cells, including MDR cells, resort to glycolysis for ener...

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Main Authors: Milane, Lara, Duan, Zhenfeng, Amiji, Mansoor
Format: Artigo
Sprog:Inglês
Udgivet: BioMed Central 2011
Fag:
Primary Research
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3045873/
https://ncbi.nlm.nih.gov/pubmed/21320311
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1475-2867-11-3
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