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Verification of alternative splicing variants based on domain integrity, truncation length and intrinsic protein disorder

According to current estimations ∼95% of multi-exonic human protein-coding genes undergo alternative splicing (AS). However, for 4000 human proteins in PDB, only 14 human proteins have structures of at least two alternative isoforms. Surveying these structural isoforms revealed that the maximum inse...

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Bibliografski detalji
Glavni autori: Hegyi, Hedi, Kalmar, Lajos, Horvath, Tamas, Tompa, Peter
Format: Artigo
Jezik:Inglês
Izdano: Oxford University Press 2011
Teme:
Online pristup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3045584/
https://ncbi.nlm.nih.gov/pubmed/20972208
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gkq843
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