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Verification of alternative splicing variants based on domain integrity, truncation length and intrinsic protein disorder

According to current estimations ∼95% of multi-exonic human protein-coding genes undergo alternative splicing (AS). However, for 4000 human proteins in PDB, only 14 human proteins have structures of at least two alternative isoforms. Surveying these structural isoforms revealed that the maximum inse...

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書誌詳細
主要な著者: Hegyi, Hedi, Kalmar, Lajos, Horvath, Tamas, Tompa, Peter
フォーマット: Artigo
言語:Inglês
出版事項: Oxford University Press 2011
主題:
オンライン・アクセス:https://ncbi.nlm.nih.gov/pmc/articles/PMC3045584/
https://ncbi.nlm.nih.gov/pubmed/20972208
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gkq843
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