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Verification of alternative splicing variants based on domain integrity, truncation length and intrinsic protein disorder

According to current estimations ∼95% of multi-exonic human protein-coding genes undergo alternative splicing (AS). However, for 4000 human proteins in PDB, only 14 human proteins have structures of at least two alternative isoforms. Surveying these structural isoforms revealed that the maximum inse...

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Detalhes bibliográficos
Main Authors: Hegyi, Hedi, Kalmar, Lajos, Horvath, Tamas, Tompa, Peter
Formato: Artigo
Idioma:Inglês
Publicado em: Oxford University Press 2011
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3045584/
https://ncbi.nlm.nih.gov/pubmed/20972208
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gkq843
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