A Mathematical Model of Tumour and Blood pHe Regulation: The [Formula: see text] Buffering System

Malignant tumours are characterised by a low, acidic extracellular pH (pHe) which facilitates invasion and metastasis. Previous research has proposed the potential benefits of manipulating systemic pHe, and recent experiments have highlighted the potential for buffer therapy to raise tumour pHe, pre...

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Main Authors: Martin, Natasha K., Gaffney, Eamonn A., Gatenby, Robert A., Gillies, Robert J., Robey, Ian F., Maini, Philip K.
Formato: Artigo
Idioma:Inglês
Publicado: 2010
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Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC3045481/
https://ncbi.nlm.nih.gov/pubmed/21167185
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.mbs.2010.12.002
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