Cellular stress-induced up-regulation of FMRP promotes cell survival by modulating PI3K-Akt phosphorylation cascades

BACKGROUND: Fragile X syndrome (FXS), the most commonly inherited mental retardation and single gene cause of autistic spectrum disorder, occurs when the Fmr1 gene is mutated. The product of Fmr1, fragile X linked mental retardation protein (FMRP) is widely expressed in HeLa cells, however the roles...

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Detalhes bibliográficos
Main Authors: Jeon, Se Jin, Seo, Jung Eun, Yang, Sung-Il, Choi, Ji Woong, Wells, David, Shin, Chan Young, Ko, Kwang Ho
Formato: Artigo
Idioma:Inglês
Publicado em: BioMed Central 2011
Assuntos:
Research
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3045291/
https://ncbi.nlm.nih.gov/pubmed/21314987
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1423-0127-18-17
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