Asparagine and Aspartate Hydroxylation of the Cytoskeletal Ankyrin Family Is Catalyzed by Factor-inhibiting Hypoxia-inducible Factor

Factor-inhibiting hypoxia-inducible factor (FIH) catalyzes the β-hydroxylation of an asparagine residue in the C-terminal transcriptional activation domain of the hypoxia inducible factor (HIF), a modification that negatively regulates HIF transcriptional activity. FIH also catalyzes the hydroxylati...

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Autors principals: Yang, Ming, Ge, Wei, Chowdhury, Rasheduzzaman, Claridge, Timothy D. W., Kramer, Holger B., Schmierer, Bernhard, McDonough, Michael A., Gong, Lingzhi, Kessler, Benedikt M., Ratcliffe, Peter J., Coleman, Mathew L., Schofield, Christopher J.
Format: Artigo
Idioma:Inglês
Publicat: American Society for Biochemistry and Molecular Biology 2011
Matèries:
Signal Transduction
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3045019/
https://ncbi.nlm.nih.gov/pubmed/21177872
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M110.193540
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