Mitochondrial fission and cristae disruption increase the response of cell models of Huntington's disease to apoptotic stimuli

Huntington's disease (HD), a genetic neurodegenerative disease caused by a polyglutamine expansion in the Huntingtin (Htt) protein, is accompanied by multiple mitochondrial alterations. Here, we show that mitochondrial fragmentation and cristae alterations characterize cellular models of HD and...

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Detalhes bibliográficos
Main Authors: Costa, Veronica, Giacomello, Marta, Hudec, Roman, Lopreiato, Raffaele, Ermak, Gennady, Lim, Dmitri, Malorni, Walter, Davies, Kelvin J A, Carafoli, Ernesto, Scorrano, Luca
Formato: Artigo
Idioma:Inglês
Publicado em: WILEY-VCH Verlag 2010
Assuntos:
Research Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3044888/
https://ncbi.nlm.nih.gov/pubmed/21069748
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/emmm.201000102
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