Bubble-chip analysis of human origin distributions demonstrates on a genomic scale significant clustering into zones and significant association with transcription

We have used a novel bubble-trapping procedure to construct nearly pure and comprehensive human origin libraries from early S- and log-phase HeLa cells, and from log-phase GM06990, a karyotypically normal lymphoblastoid cell line. When hybridized to ENCODE tiling arrays, these libraries illuminated...

Disgrifiad llawn

Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Prif Awduron: Mesner, Larry D., Valsakumar, Veena, Karnani, Neerja, Dutta, Anindya, Hamlin, Joyce L., Bekiranov, Stefan
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: Cold Spring Harbor Laboratory Press 2011
Pynciau:
Research
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC3044852/
https://ncbi.nlm.nih.gov/pubmed/21173031
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1101/gr.111328.110
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