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AID Induces Double-Strand Breaks at Immunoglobulin Switch Regions and c-MYC Causing Chromosomal Translocations in Yeast THO Mutants
Transcription of the switch (S) regions of immunoglobulin genes in B cells generates stable R-loops that are targeted by Activation Induced Cytidine Deaminase (AID), triggering class switch recombination (CSR), as well as translocations with c-MYC responsible for Burkitt's lymphomas. In Sacchar...
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| Main Authors: | , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado: |
Public Library of Science
2011
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| Acceso en liña: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3044682/ https://ncbi.nlm.nih.gov/pubmed/21383964 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pgen.1002009 |
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