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Designing substrate specificity by protein engineering of electrostatic interactions.
Protein engineering of electrostatic interactions between charged substrates and complementary charged amino acids, at two different sites in the substrate binding cleft of the protease subtilisin BPN', increases kcat/Km toward complementary charged substrates (up to 1900 times) and decreases k...
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| Pubblicato in: | Proc Natl Acad Sci U S A |
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| Autori principali: | , , , , |
| Natura: | Artigo |
| Lingua: | Inglês |
| Pubblicazione: |
National Academy of Sciences
1987
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| Soggetti: | |
| Accesso online: | https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC304398/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/3547407/ https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.84.5.1219 |
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