Dynamic Changes in the Copy Number of Pluripotency and Cell Proliferation Genes in Human ES and iPS Cells during Reprogramming and Time in Culture

Genomic stability is critical for the clinical use of human embryonic and induced pluripotent stem cells. We performed high resolution SNP (single nucleotide polymorphism) analysis on 186 pluripotent and 119 non-pluripotent samples. We report a higher frequency of subchromosomal copy number variatio...

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Autors principals: Laurent, Louise C., Ulitsky, Igor, Slavin, Ileana, Tran, Ha, Schork, Andrew, Morey, Robert, Lynch, Candace, Harness, Julie V., Lee, Sunray, Barrero, Maria J., Ku, Sherman, Martynova, Marina, Semechkin, Ruslan, Galat, Vasiliy, Gottesfeld, Joel, Belmonte, Juan Carlos Izpisua, Murry, Chuck, Keirstead, Hans S., Park, Hyun-Sook, Schmidt, Uli, Laslett, Andrew L., Muller, Franz-Josef, Nievergelt, Caroline M., Shamir, Ron, Loring, Jeanne F.
Format: Artigo
Idioma:Inglês
Publicat: 2011
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Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3043464/
https://ncbi.nlm.nih.gov/pubmed/21211785
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.stem.2010.12.003
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