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Macro Histone Variants Are Critical for the Differentiation of Human Pluripotent Cells

We have previously shown that macro histone variants (macroH2A) are expressed at low levels in stem cells and are up-regulated during differentiation. Here we show that the knockdown of macro histone variants impaired the in vitro and in vivo differentiation of human pluripotent cells, likely throug...

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Detalhes bibliográficos
Main Authors: Barrero, María J., Sese, Borja, Martí, Mercè, Izpisua Belmonte, Juan Carlos
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2013
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3668766/
https://ncbi.nlm.nih.gov/pubmed/23595991
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M113.466144
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