Marginal increase of sunitinib exposure by grapefruit juice

PURPOSE: The drug label of sunitinib includes a warning for concomitant use of grapefruit juice (GJ) but clinical evidence for this drug interaction is lacking. The aim of this study is to determine the effect of GJ, a potent intestinal cytochrome P450 (CYP) 3A4 inhibitor, on steady-state sunitinib...

Deskribapen osoa

Gorde:
Xehetasun bibliografikoak
Egile Nagusiak: van Erp, Nielka P., Baker, Sharyn D., Zandvliet, Anthe S., Ploeger, Bart A., den Hollander, Margaret, Chen, Zhaoyuan, den Hartigh, Jan, König-Quartel, Jacqueline M. C., Guchelaar, Henk-Jan, Gelderblom, Hans
Formatua: Artigo
Hizkuntza:Inglês
Argitaratua: Springer-Verlag 2010
Gaiak:
Original Article
Sarrera elektronikoa:https://ncbi.nlm.nih.gov/pmc/articles/PMC3043256/
https://ncbi.nlm.nih.gov/pubmed/20512335
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s00280-010-1367-0
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