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Ultrasensitivity in Multisite Phosphorylation of Membrane-Anchored Proteins

Cellular signaling is initially confined to the plasma membrane, where the cytoplasmic tails of surface receptors and other membrane-anchored proteins are phosphorylated in response to ligand binding. These proteins often contain multiple phosphorylation sites that are regulated by membrane-confined...

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Detalhes bibliográficos
Main Authors: Dushek, Omer, van der Merwe, P.Anton, Shahrezaei, Vahid
Formato: Artigo
Idioma:Inglês
Publicado em: The Biophysical Society 2011
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3043222/
https://ncbi.nlm.nih.gov/pubmed/21354391
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bpj.2011.01.060
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