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Understanding TR Binding to pMHC Complexes: How Does a TR Scan Many pMHC Complexes yet Preferentially Bind to One

Understanding the basis of the binding of a T cell receptor (TR) to the peptide-MHC (pMHC) complex is essential due to the vital role it plays in adaptive immune response. We describe the use of computed binding (free) energy (BE), TR paratope, pMHC epitope, molecular surface electrostatic potential...

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Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Prif Awduron: Khan, Javed Mohammed, Ranganathan, Shoba
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: Public Library of Science 2011
Pynciau:
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC3043089/
https://ncbi.nlm.nih.gov/pubmed/21364947
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0017194
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