Replacement of lysine residue 1030 in the putative ATP-binding region of the insulin receptor abolishes insulin- and antibody-stimulated glucose uptake and receptor kinase activity.

To test whether the tyrosine kinase activity of the insulin receptor is crucial for insulin action, we have constructed mutations of the human insulin receptor at Lys-1030, which is in the presumed ATP-binding region. By using oligonucleotide-directed mutagenesis, this lysine residue was replaced wi...

Descripción completa

Detalles Bibliográficos

Publicado en:	Proc Natl Acad Sci U S A
Autores principales:	Ebina, Y, Araki, E, Taira, M, Shimada, F, Mori, M, Craik, C S, Siddle, K, Pierce, S B, Roth, R A, Rutter, W J
Formato:	Artigo
Lenguaje:	Inglês
Publicado:	National Academy of Sciences 1987
Materias:	Research Article
Acceso en línea:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC304284/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/3101064/ https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.84.3.704
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!