Replacement of lysine residue 1030 in the putative ATP-binding region of the insulin receptor abolishes insulin- and antibody-stimulated glucose uptake and receptor kinase activity.

To test whether the tyrosine kinase activity of the insulin receptor is crucial for insulin action, we have constructed mutations of the human insulin receptor at Lys-1030, which is in the presumed ATP-binding region. By using oligonucleotide-directed mutagenesis, this lysine residue was replaced wi...

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Detalhes bibliográficos

Publicado no:	Proc Natl Acad Sci U S A
Principais autores:	Ebina, Y, Araki, E, Taira, M, Shimada, F, Mori, M, Craik, C S, Siddle, K, Pierce, S B, Roth, R A, Rutter, W J
Formato:	Artigo
Idioma:	Inglês
Publicado em:	National Academy of Sciences 1987
Assuntos:	Research Article
Acesso em linha:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC304284/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/3101064/ https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.84.3.704
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