Identification of a Chemical That Inhibits the Mycobacterial UvrABC Complex in Nucleotide Excision Repair

[Image: see text] Bacterial DNA can be damaged by reactive nitrogen and oxygen intermediates (RNI and ROI) generated by host immunity, as well as by antibiotics that trigger bacterial production of ROI. Thus a pathogen’s ability to repair its DNA may be important for persistent infection. A prominen...

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Huvudupphovsmän: Mazloum, Nayef, Stegman, Melanie A., Croteau, Deborah L., Van Houten, Bennett, Kwon, Nyoun Soo, Ling, Yan, Dickinson, Caitlyn, Venugopal, Aditya, Towheed, Mohammad Atif, Nathan, Carl
Materialtyp: Artigo
Språk:Inglês
Publicerad: American Chemical Society 2011
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC3042777/
https://ncbi.nlm.nih.gov/pubmed/21235228
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/bi101674c
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