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The N-Terminus of the Intrinsically Disordered Protein α-Synuclein Triggers Membrane Binding and Helix Folding

Alpha-synuclein (αS) is a 140-amino-acid protein that is involved in a number of neurodegenerative diseases. In Parkinson's disease, the protein is typically encountered in intracellular, high-molecular-weight aggregates. Although αS is abundant in the presynaptic terminals of the central nervo...

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Detalhes bibliográficos
Main Authors: Bartels, Tim, Ahlstrom, Logan S., Leftin, Avigdor, Kamp, Frits, Haass, Christian, Brown, Michael F., Beyer, Klaus
Formato: Artigo
Idioma:Inglês
Publicado em: The Biophysical Society 2010
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3042581/
https://ncbi.nlm.nih.gov/pubmed/20923645
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bpj.2010.06.035
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