Antigenic variation in Treponema pallidum: TprK sequence diversity accumulates in response to immune pressure during experimental syphilis

Pathogens that cause chronic infections often employ antigenic variation to evade the immune response and persist in the host. In Treponema pallidum (T. pallidum), the causative agent of syphilis, the TprK antigen undergoes variation of seven variable regions (V1-V7) by nonreciprocal recombination o...

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Hoofdauteurs: Giacani, Lorenzo, Molini, Barbara J., Kim, Eric Y., Godornes, B. Charmie, Leader, B. Troy, Tantalo, Lauren C., Centurion-Lara, Arturo, Lukehart, Sheila A.
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: 2010
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Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3042355/
https://ncbi.nlm.nih.gov/pubmed/20190145
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4049/jimmunol.0902788
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