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Antigenic variation in Treponema pallidum: TprK sequence diversity accumulates in response to immune pressure during experimental syphilis

Pathogens that cause chronic infections often employ antigenic variation to evade the immune response and persist in the host. In Treponema pallidum (T. pallidum), the causative agent of syphilis, the TprK antigen undergoes variation of seven variable regions (V1-V7) by nonreciprocal recombination o...

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Détails bibliographiques
Auteurs principaux: Giacani, Lorenzo, Molini, Barbara J., Kim, Eric Y., Godornes, B. Charmie, Leader, B. Troy, Tantalo, Lauren C., Centurion-Lara, Arturo, Lukehart, Sheila A.
Format: Artigo
Langue:Inglês
Publié: 2010
Sujets:
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC3042355/
https://ncbi.nlm.nih.gov/pubmed/20190145
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4049/jimmunol.0902788
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