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Identification of SR8278, a Synthetic Antagonist of the Nuclear Heme Receptor REV-ERB
REV-ERBα is a member of the nuclear receptor superfamily that functions as a receptor for the porphoryin heme. REV-ERBα suppresses transcription of its target genes in a heme-dependent manner. Recently, the first non-porphyrin synthetic ligand for REV-ERBα GSK4112, was designed and it mimics the act...
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| Main Authors: | , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2010
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3042041/ https://ncbi.nlm.nih.gov/pubmed/21043485 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/cb1002575 |
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