The ZEB1/miR-200 feedback loop controls Notch signalling in cancer cells

Notch signalling is important for development and tissue homeostasis and activated in many human cancers. Nevertheless, mutations in Notch pathway components are rare in solid tumours. ZEB1 is an activator of an epithelial–mesenchymal transition (EMT) and has crucial roles in tumour progression towa...

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Main Authors: Brabletz, Simone, Bajdak, Karolina, Meidhof, Simone, Burk, Ulrike, Niedermann, Gabriele, Firat, Elke, Wellner, Ulrich, Dimmler, Arno, Faller, Gerhard, Schubert, Jörg, Brabletz, Thomas
格式: Artigo
語言:Inglês
出版: Nature Publishing Group 2011
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在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC3041948/
https://ncbi.nlm.nih.gov/pubmed/21224848
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/emboj.2010.349
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