The ZEB1/miR-200 feedback loop controls Notch signalling in cancer cells

Notch signalling is important for development and tissue homeostasis and activated in many human cancers. Nevertheless, mutations in Notch pathway components are rare in solid tumours. ZEB1 is an activator of an epithelial–mesenchymal transition (EMT) and has crucial roles in tumour progression towa...

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Detalhes bibliográficos
Main Authors: Brabletz, Simone, Bajdak, Karolina, Meidhof, Simone, Burk, Ulrike, Niedermann, Gabriele, Firat, Elke, Wellner, Ulrich, Dimmler, Arno, Faller, Gerhard, Schubert, Jörg, Brabletz, Thomas
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group 2011
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3041948/
https://ncbi.nlm.nih.gov/pubmed/21224848
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/emboj.2010.349
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