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Mitochondrial base excision repair in mouse synaptosomes during normal aging and in a model of Alzheimer’s disease

Brain aging is associated with synaptic decline and cognitive impairment. Increased levels of oxidative DNA base damage and accumulation of mitochondrial DNA (mtDNA) mutations or deletions lead to mitochondrial dysfunction, playing an important role in the aging process and the pathogenesis of neuro...

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Autores principales: Gredilla, Ricardo, Weissman, Lior, Yang, Jenq-Lin, Bohr, Vilhelm A., Stevnsner, Tinna
Formato: Artigo
Lenguaje:Inglês
Publicado: 2010
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Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC3041866/
https://ncbi.nlm.nih.gov/pubmed/20708822
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.neurobiolaging.2010.06.019
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