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Mitochondrial base excision repair in mouse synaptosomes during normal aging and in a model of Alzheimer’s disease
Brain aging is associated with synaptic decline and cognitive impairment. Increased levels of oxidative DNA base damage and accumulation of mitochondrial DNA (mtDNA) mutations or deletions lead to mitochondrial dysfunction, playing an important role in the aging process and the pathogenesis of neuro...
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| Hlavní autoři: | , , , , |
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| Médium: | Artigo |
| Jazyk: | Inglês |
| Vydáno: |
2010
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| Témata: | |
| On-line přístup: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3041866/ https://ncbi.nlm.nih.gov/pubmed/20708822 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.neurobiolaging.2010.06.019 |
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