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Modulation of 3-hydroxy-3-methylglutaryl-CoA reductase by changes in microsomal cholesterol content or phospholipid composition.

Microsomal preparations from normal human skin fibroblasts were used to investigate the role of free cholesterol in the endoplasmic reticulum in the control of cholesterol biosynthesis by regulation of 3-hydroxy-3-methylglutaryl-coenzyme A reductase (NADPH) [(S)-mevalonate:NADP+ oxidoreductase (CoA-...

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Publicat a:Proc Natl Acad Sci U S A
Autors principals: Davis, P J, Poznansky, M J
Format: Artigo
Idioma:Inglês
Publicat: National Academy of Sciences 1987
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Accés en línia:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC304153/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/3467343/
https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.84.1.118
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