A new method for generating point mutations in bacterial artificial chromosomes by homologous recombination in Escherichia coli

Bacterial artificial chromosomes (BACs) and P1 artificial chromosomes (PACs), which contain large fragments of genomic DNA, have been successfully used as transgenes to create mouse models of dose-dependent diseases. They are also potentially valuable as transgenes for dominant diseases given that p...

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Pubblicato in:	Nucleic Acids Res
Autori principali:	Lalioti, Maria D., Heath, John K.
Natura:	Artigo
Lingua:	Inglês
Pubblicazione:	Oxford University Press 2001
Soggetti:	NAR Methods Online
Accesso online:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC30415/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/11160916/ https://ncbi.nlm.nih.govhttps://doi.org/10.1093/nar/29.3.e14
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