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Acute insulin action requires insulin receptor kinase activity: introduction of an inhibitory monoclonal antibody into mammalian cells blocks the rapid effects of insulin.

The role of the insulin receptor tyrosine kinase (protein-tyrosine kinase, EC 2.7.1.112) in various rapid insulin effects was studied by injecting four different cell types (by osmotic lysis of pinocytotic vesicles) with a monoclonal antibody that specifically inhibits the kinase activity of the ins...

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Библиографические подробности
Главные авторы: Morgan, D O, Roth, R A
Формат: Artigo
Язык:Inglês
Опубликовано: 1987
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Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC304137/
https://ncbi.nlm.nih.gov/pubmed/3540958
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