Hypoxia-inducible factor 2α (HIF-2α) heterozygous-null mice exhibit exaggerated carotid body sensitivity to hypoxia, breathing instability, and hypertension

Cardiorespiratory functions in mammals are exquisitely sensitive to changes in arterial O(2) levels. Hypoxia-inducible factors (e.g., HIF-1 and HIF-2) mediate transcriptional responses to reduced oxygen availability. We demonstrate that haploinsufficiency for the O(2)-regulated HIF-2α subunit result...

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Main Authors: Peng, Ying-Jie, Nanduri, Jayasri, Khan, Shakil A., Yuan, Guoxiang, Wang, Ning, Kinsman, Brian, Vaddi, Damodara R., Kumar, Ganesh K., Garcia, Joseph A., Semenza, Gregg L., Prabhakar, Nanduri R.
Format: Artigo
Sprog:Inglês
Udgivet: National Academy of Sciences 2011
Fag:
Biological Sciences
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3041114/
https://ncbi.nlm.nih.gov/pubmed/21288809
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1100064108
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