N(ε)-lysine acetylation determines dissociation from GAP junctions and lateralization of connexin 43 in normal and dystrophic heart

Wanting to explore the epigenetic basis of Duchenne cardiomyopathy, we found that global histone acetylase activity was abnormally elevated and the acetylase P300/CBP-associated factor (PCAF) coimmunoprecipitated with connexin 43 (Cx43), which was N(ε)-lysine acetylated and lateralized in mdx heart....

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Detalhes bibliográficos
Main Authors: Colussi, Claudia, Rosati, Jessica, Straino, Stefania, Spallotta, Francesco, Berni, Roberta, Stilli, Donatella, Rossi, Stefano, Musso, Ezio, Macchi, Emilio, Mai, Antonello, Sbardella, Gianluca, Castellano, Sabrina, Chimenti, Cristina, Frustaci, Andrea, Nebbioso, Angela, Altucci, Lucia, Capogrossi, Maurizio C., Gaetano, Carlo
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 2011
Assuntos:
Biological Sciences
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3041095/
https://ncbi.nlm.nih.gov/pubmed/21282606
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1013124108
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