N(ε)-lysine acetylation determines dissociation from GAP junctions and lateralization of connexin 43 in normal and dystrophic heart

Wanting to explore the epigenetic basis of Duchenne cardiomyopathy, we found that global histone acetylase activity was abnormally elevated and the acetylase P300/CBP-associated factor (PCAF) coimmunoprecipitated with connexin 43 (Cx43), which was N(ε)-lysine acetylated and lateralized in mdx heart....

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Bibliografiske detaljer
Main Authors: Colussi, Claudia, Rosati, Jessica, Straino, Stefania, Spallotta, Francesco, Berni, Roberta, Stilli, Donatella, Rossi, Stefano, Musso, Ezio, Macchi, Emilio, Mai, Antonello, Sbardella, Gianluca, Castellano, Sabrina, Chimenti, Cristina, Frustaci, Andrea, Nebbioso, Angela, Altucci, Lucia, Capogrossi, Maurizio C., Gaetano, Carlo
Format: Artigo
Sprog:Inglês
Udgivet: National Academy of Sciences 2011
Fag:
Biological Sciences
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3041095/
https://ncbi.nlm.nih.gov/pubmed/21282606
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1013124108
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