N(ε)-lysine acetylation determines dissociation from GAP junctions and lateralization of connexin 43 in normal and dystrophic heart

Wanting to explore the epigenetic basis of Duchenne cardiomyopathy, we found that global histone acetylase activity was abnormally elevated and the acetylase P300/CBP-associated factor (PCAF) coimmunoprecipitated with connexin 43 (Cx43), which was N(ε)-lysine acetylated and lateralized in mdx heart....

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Autors principals: Colussi, Claudia, Rosati, Jessica, Straino, Stefania, Spallotta, Francesco, Berni, Roberta, Stilli, Donatella, Rossi, Stefano, Musso, Ezio, Macchi, Emilio, Mai, Antonello, Sbardella, Gianluca, Castellano, Sabrina, Chimenti, Cristina, Frustaci, Andrea, Nebbioso, Angela, Altucci, Lucia, Capogrossi, Maurizio C., Gaetano, Carlo
Format: Artigo
Idioma:Inglês
Publicat: National Academy of Sciences 2011
Matèries:
Biological Sciences
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3041095/
https://ncbi.nlm.nih.gov/pubmed/21282606
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1013124108
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