A Nitric Oxide-dependent Cross-talk between Class I and III Histone Deacetylases Accelerates Skin Repair

In a mouse model of skin repair we found that the class I-IIa histone deacetylase inhibitor trichostatin A accelerated tissue regeneration. Unexpectedly, this effect was suppressed by Sirtinol, a class III histone deacetylase (HDAC) (sirtuin)-selective inhibitor. The role of sirtuins (SIRTs) was the...

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Detalhes bibliográficos
Main Authors: Spallotta, Francesco, Cencioni, Chiara, Straino, Stefania, Nanni, Simona, Rosati, Jessica, Artuso, Simona, Manni, Isabella, Colussi, Claudia, Piaggio, Giulia, Martelli, Fabio, Valente, Sergio, Mai, Antonello, Capogrossi, Maurizio C., Farsetti, Antonella, Gaetano, Carlo
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2013
Assuntos:
Cell Biology
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3630901/
https://ncbi.nlm.nih.gov/pubmed/23463510
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M112.441816
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