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Intramolecular proton shuttle supports not only catalytic but also noncatalytic function of carbonic anhydrase II
Carbonic anhydrases (CAs) catalyze the reversible hydration of CO(2) to HCO(3)(−) and H(+). The rate-limiting step in this reaction is the shuttle of protons between the catalytic center of the enzyme and the bulk solution. In carbonic anhydrase II (CAII), the fastest and most wide-spread isoform, t...
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| Main Authors: | , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
National Academy of Sciences
2011
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3041061/ https://ncbi.nlm.nih.gov/pubmed/21282642 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1014293108 |
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