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Normal and leukemic hematopoiesis: Are leukemias a stem cell disorder or a reacquisition of stem cell characteristics?

Leukemia can be viewed as a newly formed, abnormal hematopoietic tissue initiated by a few leukemic stem cells (LSCs) that undergo an aberrant and poorly regulated process of organogenesis analogous to that of normal hematopoietic stem cells. A hallmark of all cancers is the capacity for unlimited s...

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Bibliografiske detaljer
Main Authors: Passegué, Emmanuelle, Jamieson, Catriona H. M., Ailles, Laurie E., Weissman, Irving L.
Format: Artigo
Sprog:Inglês
Udgivet: National Academy of Sciences 2003
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC304096/
https://ncbi.nlm.nih.gov/pubmed/14504387
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.2034201100
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