Intracerebroventricular Leptin Infusion Improves Glucose Homeostasis in Lean Type 2 Diabetic MKR Mice via Hepatic Vagal and Non-Vagal Mechanisms

MKR mice, lacking insulin-like growth factor 1 receptor (IGF-1R) signaling in skeletal muscle, are lean yet hyperlipidemic, hyperinsulinemic, and hyperglycemic, with severe insulin resistance and elevated hepatic and skeletal muscle levels of triglycerides. We have previously shown that chronic peri...

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Bibliografiske detaljer
Main Authors: Li, Xiaosong, Wu, Xhiping, Camacho, Raul, Schwartz, Gary J., LeRoith, Derek
Format: Artigo
Sprog:Inglês
Udgivet: Public Library of Science 2011
Fag:
Research Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3040739/
https://ncbi.nlm.nih.gov/pubmed/21379576
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0017058
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