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Physiological response to long-term peripheral and central leptin infusion in lean and obese mice

Recent data have identified leptin as an afferent signal in a negative-feedback loop regulating the mass of the adipose tissue. High leptin levels are observed in obese humans and rodents, suggesting that, in some cases, obesity is the result of leptin insensitivity. This hypothesis was tested by co...

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Autores principales: Halaas, Jeffrey L., Boozer, Carol, Blair-West, John, Fidahusein, Naseem, Denton, Derek A., Friedman, Jeffrey M.
Formato: Artigo
Lenguaje:Inglês
Publicado: The National Academy of Sciences of the USA 1997
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Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC23177/
https://ncbi.nlm.nih.gov/pubmed/9238071
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