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Tumour microvesicles contain retrotransposon elements and amplified oncogene sequences

Tumour cells release an abundance of microvesicles containing a selected set of proteins and RNAs. Here, we show that tumour microvesicles also carry DNA, which reflects the genetic status of the tumour, including amplification of the oncogene c-Myc. We also find amplified c-Myc in serum microvesicl...

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Hlavní autoři: Balaj, Leonora, Lessard, Ryan, Dai, Lixin, Cho, Yoon-Jae, Pomeroy, Scott L., Breakefield, Xandra O., Skog, Johan
Médium: Artigo
Jazyk:Inglês
Vydáno: 2011
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On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3040683/
https://ncbi.nlm.nih.gov/pubmed/21285958
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ncomms1180
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