Secreted Bacterial Effectors That Inhibit Host Protein Synthesis Are Critical for Induction of the Innate Immune Response to Virulent Legionella pneumophila

The intracellular bacterial pathogen Legionella pneumophila causes an inflammatory pneumonia called Legionnaires' Disease. For virulence, L. pneumophila requires a Dot/Icm type IV secretion system that translocates bacterial effectors to the host cytosol. L. pneumophila lacking the Dot/Icm syst...

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Hlavní autoři: Fontana, Mary F., Banga, Simran, Barry, Kevin C., Shen, Xihui, Tan, Yunhao, Luo, Zhao-Qing, Vance, Russell E.
Médium: Artigo
Jazyk:Inglês
Vydáno: Public Library of Science 2011
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Research Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3040669/
https://ncbi.nlm.nih.gov/pubmed/21390206
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.ppat.1001289
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