Safety, tolerability and pharmacokinetics of an intravenous bolus of sildenafil in patients with pulmonary arterial hypertension

AIMS: To assess pharmacokinetics and pharmacodynamics of a 10 mg intravenous sildenafil bolus in pulmonary arterial hypertension (PAH) patients stabilized on 20 mg sildenafil orally three times daily. METHODS: Pharmacokinetic parameters were calculated using noncompartmental analysis. RESULTS: After...

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Autors principals: Vachiery, Jean-Luc, Huez, Sandrine, Gillies, Hunter, Layton, Gary, Hayashi, Naoto, Gao, Xiang, Naeije, Robert
Format: Artigo
Idioma:Inglês
Publicat: Blackwell Science Inc 2011
Matèries:
Short Reports
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3040551/
https://ncbi.nlm.nih.gov/pubmed/21219411
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/j.1365-2125.2010.03831.x
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