Influence of polymorphisms within the methotrexate pathway genes on the toxicity and efficacy of methotrexate in patients with juvenile idiopathic arthritis

AIMS: We investigated whether several polymorphisms within the methotrexate (MTX) pathway genes were related to the toxicity and efficacy of MTX in 92 Japanese patients with articular-type juvenile idiopathic arthritis (JIA). METHODS: Eight gene polymorphisms within the MTX pathway genes, namely, RF...

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Detalhes bibliográficos
Main Authors: Yanagimachi, Masakatsu, Naruto, Takuya, Hara, Takuma, Kikuchi, Masako, Hara, Ryoki, Miyamae, Takako, Imagawa, Tomoyuki, Mori, Masaaki, Kaneko, Tetsuji, Morita, Satoshi, Goto, Hiroaki, Yokota, Shumpei
Formato: Artigo
Idioma:Inglês
Publicado em: Blackwell Science Inc 2011
Assuntos:
Paediatric Clinical Pharmacology
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3040544/
https://ncbi.nlm.nih.gov/pubmed/21219404
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/j.1365-2125.2010.03814.x
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