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Chronic norepinephrine elicits desensitization by uncoupling the beta-receptor.
The goal of this study was to determine the mechanism of beta-adrenergic receptor desensitization after chronic elevation of circulating NE levels. Osmotic minipumps containing either NE or saline were implanted subcutaneously in dogs for 3-4 wk. Physiologic desensitization to isoproterenol was conf...
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| Publicado no: | J Clin Invest |
|---|---|
| Main Authors: | , , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
American Society for Clinical Investigation
1989
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC304050/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/2556443/ https://ncbi.nlm.nih.govhttps://doi.org/10.1172/JCI114357 |
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