Chronic norepinephrine elicits desensitization by uncoupling the beta-receptor.

The goal of this study was to determine the mechanism of beta-adrenergic receptor desensitization after chronic elevation of circulating NE levels. Osmotic minipumps containing either NE or saline were implanted subcutaneously in dogs for 3-4 wk. Physiologic desensitization to isoproterenol was conf...

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Main Authors: Vatner, D E, Vatner, S F, Nejima, J, Uemura, N, Susanni, E E, Hintze, T H, Homcy, C J
Format: Artigo
Jezik:Inglês
Izdano: 1989
Teme:
Research Article
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC304050/
https://ncbi.nlm.nih.gov/pubmed/2556443
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