Chronic norepinephrine elicits desensitization by uncoupling the beta-receptor.

The goal of this study was to determine the mechanism of beta-adrenergic receptor desensitization after chronic elevation of circulating NE levels. Osmotic minipumps containing either NE or saline were implanted subcutaneously in dogs for 3-4 wk. Physiologic desensitization to isoproterenol was conf...

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Publié dans:	J Clin Invest
Auteurs principaux:	Vatner, D E, Vatner, S F, Nejima, J, Uemura, N, Susanni, E E, Hintze, T H, Homcy, C J
Format:	Artigo
Langue:	Inglês
Publié:	American Society for Clinical Investigation 1989
Sujets:	Research Article
Accès en ligne:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC304050/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/2556443/ https://ncbi.nlm.nih.govhttps://doi.org/10.1172/JCI114357
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