Nitric oxide controls an inflammatory-like Ly6C(hi)PDCA1(+) DC subset that regulates Th1 immune responses

Using NOS2 KO mice, we investigated the hypothesis that NO modulation of BM-DC contributes to the NO-mediated control of Th1 immune responses. BM-DCs from NOS2 KO mice, compared with WT BM-DCs, have enhanced survival and responsiveness to TLR agonists, develop more Ly6C(hi)PDCA1(+) DCs that resemble...

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Bibliographic Details
Main Authors: Giordano, Daniela, Li, Chang, Suthar, Mehul S., Draves, Kevin E., Ma, Daphne Y., Gale, Michael, Clark, Edward A.
Format: Artigo
Language:Inglês
Published: Society for Leukocyte Biology 2011
Subjects:
Host Defense & Pathophysiology
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3040463/
https://ncbi.nlm.nih.gov/pubmed/21178115
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1189/jlb.0610329
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