Synthesis and Pharmacological Evaluation of the Stereoisomersof 3-Carba Cyclic-Phosphatidic Acid

Cyclic phosphatidic acid (CPA) is a naturally occurring analog of lysophosphatidic acid (LPA) in which the sn-2 hydroxy group forms a 5-membered ring with the sn-3 phosphate. Here we describe the synthesis of R-3-CCPA and S-3-CCPA along with their pharmacological properties as inhibitors of lysophos...

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Bibliografiske detaljer
Main Authors: Gupte, Renuka, Siddam, Anjaih, Lu, Yan, Li, Wei, Fujiwara, Yuko, Panupinthu, Nattapon, Truc-ChiPham, Baker, Daniel L., Parrill, Abby L., Gotoh, Mari, Murakami-Murofushi, Kimiko, Mills, Gordon B., Tigyi, Gabor, Miller, Duane D.
Format: Artigo
Sprog:Inglês
Udgivet: 2010
Fag:
Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3040411/
https://ncbi.nlm.nih.gov/pubmed/21051230
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bmcl.2010.09.115
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