Carba analogs of cyclic phosphatidic acid are selective inhibitors of autotaxin and cancer cell invasion and metastasis

Autotaxin (ATX, nucleotide pyrophosphate/phosphodiesterase-2, NPP2) is an autocrine motility factor initially characterized from A2058 melanoma cell conditioned medium. ATX is known to contribute to cancer cell survival, growth, and invasion. Recently ATX was shown to be responsible for the lysophos...

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Autori principali: Baker, Daniel L., Fujiwara, Yuko, Pigg, Kathryn R., Tsukahara, Ryoko, Kobayashi, Susumu, Murofushi, Hiromu, Uchiyama, Ayako, Murakami-Murofushi, Kimiko, Koh, Eunjin, Bandle, Russell W., Byun, Hoe-Sup, Bittman, Robert, Fan, Dominic, Murph, Mandi, Mills, Gordon B., Tigyi, Gabor
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2006
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC3505596/
https://ncbi.nlm.nih.gov/pubmed/16782709
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M512486200
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