Phase I/II Study of the Src Inhibitor Dasatinib in Combination With Erlotinib in Advanced Non–Small-Cell Lung Cancer

PURPOSE: Src family kinase (SFK) proteins are frequently activated in cancer and can coordinate tumor cell growth, survival, invasion, and angiogenesis. Given the importance of SFK signaling in cancer, known cooperation between SFK and epidermal growth factor receptor (EGFR) signaling, and efficacy...

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Hlavní autoři: Haura, Eric B., Tanvetyanon, Tawee, Chiappori, Alberto, Williams, Charles, Simon, George, Antonia, Scott, Gray, Jhanelle, Litschauer, Sharon, Tetteh, Leticia, Neuger, Anthony, Song, Lanxi, Rawal, Bhupendra, Schell, Michael J., Bepler, Gerold
Médium: Artigo
Jazyk:Inglês
Vydáno: American Society of Clinical Oncology 2010
Témata:
Original Reports
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3040065/
https://ncbi.nlm.nih.gov/pubmed/20142592
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1200/JCO.2009.25.4029
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