Randomized International Phase III Trial of ERCC1 and RRM1 Expression–Based Chemotherapy Versus Gemcitabine/Carboplatin in Advanced Non–Small-Cell Lung Cancer

PURPOSE: We assessed whether chemotherapy selection based on in situ ERCC1 and RRM1 protein levels would improve survival in patients with advanced non–small-cell lung cancer (NSCLC). PATIENTS AND METHODS: Eligible patients were randomly assigned 2:1 to the trial's experimental arm, which consi...

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Autori principali: Bepler, Gerold, Williams, Charles, Schell, Michael J., Chen, Wei, Zheng, Zhong, Simon, George, Gadgeel, Shirish, Zhao, Xiuhua, Schreiber, Fred, Brahmer, Julie, Chiappori, Alberto, Tanvetyanon, Tawee, Pinder-Schenck, Mary, Gray, Jhanelle, Haura, Eric, Antonia, Scott, Fischer, Juergen R.
Natura: Artigo
Lingua:Inglês
Pubblicazione: American Society of Clinical Oncology 2013
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ORIGINAL REPORTS
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC3691357/
https://ncbi.nlm.nih.gov/pubmed/23690416
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1200/JCO.2012.46.9783
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