Hexokinase 2 is a key mediator of aerobic glycolysis and promotes tumor growth in human glioblastoma multiforme

Proliferating embryonic and cancer cells preferentially use aerobic glycolysis to support growth, a metabolic alteration commonly referred to as the “Warburg effect.” Here, we show that the glycolytic enzyme hexokinase 2 (HK2) is crucial for the Warburg effect in human glioblastoma multiforme (GBM),...

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Bibliographic Details
Main Authors: Wolf, Amparo, Agnihotri, Sameer, Micallef, Johann, Mukherjee, Joydeep, Sabha, Nesrin, Cairns, Rob, Hawkins, Cynthia, Guha, Abhijit
Format: Artigo
Language:Inglês
Published: The Rockefeller University Press 2011
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Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3039857/
https://ncbi.nlm.nih.gov/pubmed/21242296
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1084/jem.20101470
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