The Wnt agonist R-spondin1 regulates systemic graft-versus-host disease by protecting intestinal stem cells

Graft-versus-host disease (GVHD) is a major complication of allogeneic bone marrow transplantation (BMT), and damage to the gastrointestinal (GI) tract plays a critical role in amplifying systemic disease. Intestinal stem cells (ISCs) play a pivotal role not only in physiological tissue renewal but...

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Main Authors: Takashima, Shuichiro, Kadowaki, Masanori, Aoyama, Kazutoshi, Koyama, Motoko, Oshima, Takeshi, Tomizuka, Kazuma, Akashi, Koichi, Teshima, Takanori
Format: Artigo
Language:Inglês
Published: The Rockefeller University Press 2011
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Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3039850/
https://ncbi.nlm.nih.gov/pubmed/21282378
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1084/jem.20101559
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