R-Spondin1 expands Paneth cells and prevents dysbiosis induced by graft-versus-host disease

The intestinal microbial ecosystem is actively regulated by Paneth cell–derived antimicrobial peptides such as α-defensins. Various disorders, including graft-versus-host disease (GVHD), disrupt Paneth cell functions, resulting in unfavorably altered intestinal microbiota (dysbiosis), which further...

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Bibliografiske detaljer
Udgivet i:J Exp Med
Main Authors: Hayase, Eiko, Hashimoto, Daigo, Nakamura, Kiminori, Noizat, Clara, Ogasawara, Reiki, Takahashi, Shuichiro, Ohigashi, Hiroyuki, Yokoi, Yuki, Sugimoto, Rina, Matsuoka, Satomi, Ara, Takahide, Yokoyama, Emi, Yamakawa, Tomohiro, Ebata, Ko, Kondo, Takeshi, Hiramine, Rina, Aizawa, Tomoyasu, Ogura, Yoshitoshi, Hayashi, Tetsuya, Mori, Hiroshi, Kurokawa, Ken, Tomizuka, Kazuma, Ayabe, Tokiyoshi, Teshima, Takanori
Format: Artigo
Sprog:Inglês
Udgivet: The Rockefeller University Press 2017
Fag:
Research Articles
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5716036/
https://ncbi.nlm.nih.gov/pubmed/29066578
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1084/jem.20170418
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