Caffeine induces apoptosis by enhancement of autophagy via PI3K/Akt/mTOR/p70S6K inhibition

Caffeine is one of the most frequently ingested neuroactive compounds. All known mechanisms of apoptosis induced by caffeine act through cell cycle modulation or p53 induction. It is currently unknown whether caffeine-induced apoptosis is associated with other cell death mechanisms, such as autophag...

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Detalhes bibliográficos
Principais autores: Saiki, Shinji, Sasazawa, Yukiko, Imamichi, Yoko, Kawajiri, Sumihiro, Fujimaki, Takahiro, Tanida, Isei, Kobayashi, Hiroki, Sato, Fumiaki, Sato, Shigeto, Ishikawa, Kei-Ichi, Imoto, Masaya, Hattori, Nobutaka
Formato: Artigo
Idioma:Inglês
Publicado em: Landes Bioscience 2011
Assuntos:
Basic Research Paper
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3039768/
https://ncbi.nlm.nih.gov/pubmed/21081844
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4161/auto.7.2.14074
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