Caffeine induces apoptosis by enhancement of autophagy via PI3K/Akt/mTOR/p70S6K inhibition

Caffeine is one of the most frequently ingested neuroactive compounds. All known mechanisms of apoptosis induced by caffeine act through cell cycle modulation or p53 induction. It is currently unknown whether caffeine-induced apoptosis is associated with other cell death mechanisms, such as autophag...

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Bibliografiske detaljer
Main Authors: Saiki, Shinji, Sasazawa, Yukiko, Imamichi, Yoko, Kawajiri, Sumihiro, Fujimaki, Takahiro, Tanida, Isei, Kobayashi, Hiroki, Sato, Fumiaki, Sato, Shigeto, Ishikawa, Kei-Ichi, Imoto, Masaya, Hattori, Nobutaka
Format: Artigo
Sprog:Inglês
Udgivet: Landes Bioscience 2011
Fag:
Basic Research Paper
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3039768/
https://ncbi.nlm.nih.gov/pubmed/21081844
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4161/auto.7.2.14074
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